Ustad Abdul Karim Khan (Devanagari: अब्दुल करीम ख़ान, Persian script: استاد عبدالکریم خان) (November 11, 1872–1937), was an Indian classical singer of the Kairana gharana (Kirana Gharana).
Abdul Karim Khan was born in Kairana village in muzaffarnagar (Uttar Pradesh, North India) in to the Kairana musical family which traced its roots to musician brothers Ghulam Ali and Ghulam Maula. His father, Kale Khan was the grandson of Ghulam Ali. Karim Khan received training under uncle Abdulla Khan and father Kale Khan. He also received guidance from another uncle Nanhe Khan. Apart from vocals and sarangi, he also learnt Veena (Been), Sitar and Tabla.